Article | 09. 2017 Vol. 1, Issue. 2
Finding the marble – The polygenic architecture of intramuscular fat

School of Environmental and Rural Science, University of New England1
Animal Genomics & Bioinformatics Division, National Institute of Animal Science2
Animal Breeding & Genetics Division, National Institute of Animal Science3
College of Agriculture & Natural Resources, Michigan State University4

2017.09. 69:76


Intramuscular fat (IMF) is one of the most important traits in the meat industry. It has been positively correlated with tenderness, juiciness and an overall improved eating experience. It also attracts premium pricing and a much clearer market signal than any other production trait. In this short review, we summarize what is known about the genetic architecture of IMF in Korean Hanwoo cattle. There is a lot of discordancy and limited validation across the many IMF studies, which we suggest is driven to a large extent by the highly polygenic nature of the trait, with individual studies capturing different facets of the trait but never the full picture. A true handle on the functional genetics of marbling will require larger projects and concerted effort between researchers, industry and government. The payoff however has potential to be very high as IMF is the main determinant of profitability in the Hanwoo industry.

1. Amos W, Harwood J (1998) Factors affecting levels of genetic diversity in natural populations. Philos Trans R Soc Lond B Biol Sci 353:177-86.  

2. Carrillo A, He Y, Li Y, Liu J, Erdman RA, Sonstegard TS, Song J (2016) Integrated metabolomic and transcriptome analyses reveal finishing forage affects metabolic pathways related to beef quality and animal welfare. Scientific reports 6:25948.  

3. Cheong HS, Yoon DH, Park BL, Kim LH, Bae JS, Namgoong S, Lee HW, Han CS, Kim JO, Cheong IC, Shin HD (2008) A single nucleotide polymorphism in CAPN1 associated with marbling score in Korean cattle. BMC Genet 9:33.  

4. Chung H, Davis M (2012) Effects of genetic variants for the calpastatin gene on calpastatin activity and meat tenderness in Hanwoo (Korean cattle). Meat Sci 90:711-4.  

5. Decker JE, McKay SD, Rolf MM, Kim J, Molina Alcala A, Sonstegard TS, Hanotte O, Gotherstrom A, Seabury CM, Praharani L, Babar ME, Correia de Almeida Regitano L, Yildiz MA, Heaton MP, Liu WS, Lei CZ, Reecy JM, Saif-Ur-Rehman M, Schnabel RD, Taylor JF (2014) Worldwide patterns of ancestry, divergence, and admixture in domesticated cattle. PLoS Genet 10:e1004254.  

6. Gotoh T, Joo S-T (2016) Characteristics and health benefit of highly marbled wagyu and hanwoo beef. Korean J Food Sci Anim Resour36:709.  

7. Jung EY, Hwang Y-H, Joo S-T (2016) The relationship between chemical compositions, meat quality, and palatability of the 10 primal cuts from Hanwoo steer. Korean J Food Sci Anim Resour 36:145.  

8. Kawaguchi N, Xu X, Tajima R, Kronqvist P, Sundberg C, Loechel F, Albrechtsen R, Wewer U (2002) ADAM12 protease induces adipogenesis in transgenic mice. A, J Pathol 160:1895-903.  

9. Kim S, Lee J, Park S (2016) Effects of full-fat soybean diet on performance, carcass characteristics, and fatty acid composition of Hanwoo steers. Turk J Vet Anim Sci 40:451-8.  

10. Kirkland JL, Tchkonia T, Pirtskhalava T, Han J, Karagiannides I (2002) Adipogenesis and aging: does aging make fat go MAD? Exp Gerontol 37:757-67.  

11. Laurenson YCSM, McPhee MJ (2014) Estimating intramuscular fat content from CT scan images. In: 8th International Workshop on Modelling Nutrient Digestion and Utilization in Farm Animals, Cairns, Australia.  

12. Lee H-J, Park H-S, Kim W, Yoon D, Seo S (2014a) Comparison of metabolic network between muscle and intramuscular adipose tissues in Hanwoo beef cattle using a systems biology approach. Int J Genomics 2014,  

13. Lee SH, Choi BH, Lim D, Gondro C, Cho YM, Dang CG, Sharma A, Jang GW, Lee KT, Yoon D (2013a) Genome-wide association study identifies major loci for carcass weight on BTA14 in Hanwoo (Korean cattle). PLoS One 8, e74677.  

14. Lee SH, Gondro C, van der Werf J, Kim NK, Lim DJ, Park EW, Oh SJ, Gibson JP, Thompson JM (2010) Use of a bovine genome array to identify new biological pathways for beef marbling in Hanwoo (Korean Cattle). BMC Genomics 11:623.  

15. Lee SH, Kim SC, Chai HH, Cho SH, Kim HC, Lim D, Choi BH, Dang CG, Sharma A, Gondro C, Yang BS, Hong SK (2014b)

16. Lee SH, Van der Werf J, Lee SH, Lim D, Park EW, Gondro C, Yoon D, Oh JD, Kim OH, Gibson JP, Thompson J (2012) Genome wide QTL mapping to identify candidate genes for carcass traits in Hanwoo (Korean Cattle). Genes & Genomics 34:43-9.  

17. Lee SH, van der Werf JH, Kim NK, Gondro C, Park EW, Oh SJ, Gibson JP, Thompson JM (2011) QTL and gene expression analyses identify genes affecting carcass weight and marbling on BTA14 in Hanwoo (Korean Cattle). Mamm Genome 22:589-601.  

18. Lee T, Cho S, Seo KS, Chang J, Kim H, Yoon D (2013b) Genetic variants and signatures of selective sweep of Hanwoo population (Korean native cattle). BMB Rep 46:346-51.  

19. Lim D, Gondro C, Park HS, Cho YM, Chai HH, Seong HH, Yang BS, Hong SK, Chang WK, Lee SH (2013) Identification of recently selected mutations driven by artificial selection in Hanwoo (Korean Cattle). Asian-Aust. J Anim Sci 26:603-8.  

20. Lim D, Gondro C, Strucken EM, Choi BH, Chai HH, Cho YM, Jang GW, Kim T-H, Lee SH (2015) Selection footprints in Korean beef cattle link alzheimer’s and meat tenderness. BMC Genomics.  

21. MacNeil MD, Nkrumah JD, Woodward BW, Northbutt SL (2010) Genetic evaluation of Angus cattle for carcass marbling using ultrasound and genomic indicators. J Anim Sci 88:517-22.  

22. Mehrban H, Lee DH, Moradi MH, IlCho C, Naserkheil M, Ibáñez-Escriche N (2017) Predictive performance of genomic selection methods for carcass traits in Hanwoo beef cattle: impacts of the genetic architecture. Genetics Selection Evolution 49:1.  

23. Nurnberg K, Wegner J, Ender K (1998) Factors influencing fat composition in muscle and adipose tissue of farm animals. Livestock Production Science 56:145-56.  

24. Panjono P, Kang S-M, Lee I-S, Kim Y-J, Lee S-K (2009) Relationship of slaughter age and carcass traits of Hanwoo cattle. Korean J Food Sci Anim Resour 29:550-6.  

25. Porto-Neto LR, Lee S-H, Sonstegard T, Van Tassell CP, Lee HK, Gondro C (2012) Genome-wide detection of signatures of selection in Korean Hanwoo cattle. Anim Genet.  

26. Sadkowski T, Ciecierska A, Majewska A, Oprządek J, Dasiewicz K, Ollik M, Wicik Z, Motyl T (2014) Transcriptional background of beef marbling—novel genes implicated in intramuscular fat deposition. Meat science 97:32-41.  

27. Strucken EM, Piper EK, Lee HK, Song KD, Gibson JP, Lee SH, Gondro C (2014) Fat cows - Selection signatures in Korean Hanwoo and Australian Wagyu cattle. In: 10th World Congress of Genetics Applied to Livestock Production, pp. 1-4, Vancouver, CA.  

28. Tang K, Thornton KR, Stoneking M (2007) A new approach for using genome scans to detect recent positive selection in the human genome. PLoS Biol 5:e171.  

29. Wang YH, Bower NI, Reverter A, Tan SH, De Jager N, Wang R, McWilliam SM, Cafe LM, Greenwood PL, Lehnert SA (2009b) Gene expression patterns during intramuscular fat development in cattle. J Anim Sci 87:119-30.  

30. Weir BS, Cockerham CC (1984) Estimating F-statistics for the analysis of population structure. Evolution 38:1358-70.  

31. Wright S (1951) The genetical structure of populations. Ann Eugenics 15:323-54.